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1

Targeting innate immune mediators in type 1 and type 2 diabetes

Donath, Marc Y., Dinarello, Charles A., Mandrup-Poulsen, Thomas

Journal:

Nature Reviews Immunology

Year:

2019

Language:

english

File:

PDF, 1.79 MB

english, 2019

2

The No-Go and Nonsense-Mediated RNA Decay Pathways are Regulated by Inflammatory Cytokines in Insulin-Producing Cells and Human Islets and Determine β-Cell Insulin Biosynthesis and Survival

Mojtaba Ghiasi, Seyed, Krogh, Nicolai, Tyrberg, Björn, Mandrup-Poulsen, Thomas

Journal:

Year:

2018

Language:

english

File:

PDF, 6.08 MB

english, 2018

3

Vitamin D Analogues in Insulin-Dependent Diabetes Mellitus and Other Autoimmune Diseases: A Therapeutic Perspective

Dídac Mauricio, Thomas Mandrup-Poulsen, Jørn Nerup

Journal:

Diabetes/Metabolism Research and Reviews

Year:

1996

Language:

english

File:

PDF, 1.02 MB

english, 1996

4

Role of IL-1β in type 2 diabetes

Dinarello, Charles A, Donath, Marc Y, Mandrup-Poulsen, Thomas

Journal:

Current Opinion in Endocrinology Diabetes and Obesity

Year:

2010

Language:

english

File:

PDF, 235 KB

english, 2010

5

16 SKELETAL-MUSCLE LIPOPROTEIN EXPRESSION IS REGULATED BY TRAINING AND TYPE 2 DIABETES IN HUMANS AND IMPROVES INSULIN SENSITIVITY IN OBESE MICE

Bartels, E., Ploug, T., Størling, J., Mandrup-Poulsen, T., Dela, F., Nielsen, L.B.

Journal:

Atherosclerosis Supplements

Year:

2011

Language:

english

File:

PDF, 40 KB

english, 2011

6

Cytokine-Induced Proapoptotic Gene Expression in Insulin-Producing Cells Is Related to Rapid, Sustained, and Nonoscillatory Nuclear Factor-κB Activation

Ortis, Fernanda, Cardozo, Alessandra K., Crispim, Daisy, Störling, Joachim, Mandrup-Poulsen, Thomas, Eizirik, Décio L.

Journal:

Molecular Endocrinology

Year:

2006

Language:

english

File:

PDF, 405 KB

english, 2006

7

TRAF2 mediates JNK and STAT3 activation in response to IL-1β and IFNγ and facilitates apoptotic death of insulin-producing β-cells

Prause, Michala, Berchtold, Lukas Adrian, Urizar, Adriana Ibarra, Hyldgaard Trauelsen, Mette, Billestrup, Nils, Mandrup-Poulsen, Thomas, Størling, Joachim

Journal:

Molecular and Cellular Endocrinology

Year:

2016

Language:

english

File:

PDF, 1.71 MB

english, 2016

8

Treatment of type 2 diabetes by targeting interleukin-1: a meta-analysis of 2921 patients

Kataria, Yachana, Ellervik, Christina, Mandrup-Poulsen, Thomas

Journal:

Seminars in Immunopathology

Year:

2019

Language:

english

File:

PDF, 633 KB

english, 2019

9

Cytokines as Immune Effector Molecules in Autoimmune Endocrine Diseases with Special Reference to Insulin-Dependent Diabetes Mellitus

Mandrup-Poulsen, Thomas, Helqvist, Steffen, Mølvig, Jens, Wogensen, Lise Dall, Nerup, Jørn

Journal:

Year:

1989

Language:

english

File:

PDF, 2.05 MB

english, 1989

10

Over-expression of Follistatin-like 3 attenuates fat accumulation and improves insulin sensitivity in mice

Brandt, Claus, Hansen, Rasmus Hvass, Hansen, Jakob Bondo, Olsen, Caroline Holkmann, Galle, Pia, Mandrup-Poulsen, Thomas, Gehl, Julie, Pedersen, Bente Klarlund, Hojman, Pernille

Journal:

Year:

2015

Language:

english

File:

PDF, 1.24 MB

english, 2015

11

Poor Pregnancy Outcome in Women With Type 2 Diabetes

Clausen, T. D., Mathiesen, E., Ekbom, P., Hellmuth, E., Mandrup-Poulsen, T., Damm, P.

Journal:

Year:

2005

Language:

english

File:

PDF, 80 KB

english, 2005

12

Strain-Dependent Differences in Sensitivity of Rat -Cells to Interleukin 1 In Vitro and In Vivo

Reimers, J. I., Anderson, H. U., Mauricio, D., Pociot, F., Karlsen, A., Peterson, J. S., Mandrup-Poulsen, T., Nerup, J.

Journal:

Year:

1996

Language:

english

File:

PDF, 1.79 MB

english, 1996

13

The oral histone deacetylase inhibitor ITF2357 reduces cytokine production, cytokine activities and protects islet β-cells in vivo and in vitro

Eli C. Lewis, Lykke Blaabjerg, Joachim Størling, Sif G. Ronn, Paolo Mascagni, Charles A. Dinarello, Thomas Mandrup-Poulsen

Journal:

Year:

2009

Language:

english

File:

PDF, 59 KB

english, 2009

14

A GENETIC MARKER FOR ATHEROSCLEROSIS?

Mandrup-Poulsen, T., Owerbach, D., Mortensen, S.A., Johansen, K., Meinertz, H., Srensen, H., Nerup, J.

Journal:

Year:

1984

Language:

english

File:

PDF, 150 KB

english, 1984

15

The use of interleukin-1-receptor antagonists in the treatment of diabetes mellitus

Donath, Marc Y, Mandrup-Poulsen, Thomas

Journal:

Nature Clinical Practice Endocrinology and Metabolism

Year:

2008

Language:

english

File:

PDF, 102 KB

english, 2008

16

IA-2 Antibody-Negative Status Predicts Remission and Recovery of C-Peptide Levels in Type 1 Diabetic Patients Treated With Cyclosporin

Christie, M. R., Molvig, J., Hawkes, C. J., Carstensen, B., Mandrup-Poulsen, T.

Journal:

Year:

2002

Language:

english

File:

PDF, 149 KB

english, 2002

17

Cytokines and the endocrine system. I. The immunoendocrine network

Mandrup-Poulsen, T., Nerup, J., Reimers, J. I, Pociot, F., Andersen, H. U, Karlsen, A., Bjerre, U., Bergholdt, R.

Journal:

European Journal of Endocrinology

Year:

1995

Language:

english

File:

PDF, 1.22 MB

english, 1995

18

Total Mortality by Elevated Transferrin Saturation in Patients With Diabetes

Ellervik, C., Andersen, H. U., Tybjaerg-Hansen, A., Frandsen, M., Birgens, H., Nordestgaard, B. G., Mandrup-Poulsen, T.

Journal:

Year:

2013

Language:

english

File:

PDF, 215 KB

english, 2013

19

Natural Course of Remission in IDDM During 1st yr After Diagnosis

Martin, S., Pawlowski, B., Greulich, B., Ziegler, A. G., Mandrup-Poulsen, T., Mahon, J.

Journal:

Year:

1992

Language:

english

File:

PDF, 967 KB

english, 1992

20

Calcium Has a Permissive Role in Interleukin-1β-Induced c-Jun N-Terminal Kinase Activation in Insulin-Secreting Cells

Størling, Joachim, Zaitsev, Sergei V., Kapelioukh, Iouri L., Karlsen, Allan E., Billestrup, Nils, Berggren, Per-Olof, Mandrup-Poulsen, Thomas

Journal:

Year:

2005

File:

PDF, 450 KB

2005

21

Extracellular signal-regulated kinase is essential for interleukin-1-induced and nuclear factor κB-mediated gene expression in insulin-producing INS-1E cells

L. Larsen, J. Størling, M. Darville, D. L. Eizirik, C. Bonny, N. Billestrup, T. Mandrup-Poulsen

Journal:

Year:

2005

Language:

english

File:

PDF, 260 KB

english, 2005

22

Dietary Supplementation with co-3-Polyunsaturated Fatty Acids Decreases Mononuclear Cell Proliferation and Interleukin-1β Content but not Monokine Secretion in Healthy and Insulin-Dependent Diabetic Individuals

J. MØLVIG, F. POCIOT, H. WORSAAE, L. D. WOGENSEN, L. BAEK, P. CHRISTENSEN, T. MANDRUP-POULSEN, K. ANDERSEN, P. MADSEN, J. DYERBERG, J. NERUP

Journal:

Scandinavian Journal of Immunology

Year:

1991

Language:

english

File:

PDF, 701 KB

english, 1991

23

Characterization of new polymorphisms in the 5′UTR of the human interleukin-1 receptor type 1 (IL1R1) gene: linkage to type 1 diabetes and correlation to IL-1RI plasma level

Bergholdt, R, Larsen, Z M, Andersen, N A, Johannesen, J, Kristiansen, O P, Mandrup-Poulsen, T, Nerup, J, Pociot, F, DSGD,, DIEGG,

Journal:

Genes and Immunity

Year:

2000

Language:

english

File:

PDF, 229 KB

english, 2000

24

RNA modifications by oxidation: A novel disease mechanism?

Henrik E. Poulsen, Elisabeth Specht, Kasper Broedbaek, Trine Henriksen, Christina Ellervik, Thomas Mandrup-Poulsen, Morten Tonnesen, Peter E. Nielsen, Henrik U. Andersen, Allan Weimann

Journal:

Free Radical Biology and Medicine

Year:

2012

Language:

english

File:

PDF, 345 KB

english, 2012

25

In Vitro Inhibition of Insulin Release by Blood Mononuclear Cells from Insulin-Dependent Diabetic and Healthy Subjects: Synergistic Action of IL-1 and TNF

Ablamunits, Vitlaly, Baranova, Flora, Mandrup-Poulsen, Thomas, Nerup, Jørn

Journal:

Cell Transplantation

Year:

1994

Language:

english

File:

PDF, 461 KB

english, 1994

26

Functional and morphological effects of interleukin-1β on the perfused rat pancreas

L. D. Wogensen, V. Kolb-Bachofen, P. Christensen, C. A. Dinarello, T. Mandrup-Poulsen, S. Martin, J. Nerup

Journal:

Year:

1990

Language:

english

File:

PDF, 2.12 MB

english, 1990

27

IL-1β-induced pro-apoptotic signalling is facilitated by NCAM/FGF receptor signalling and inhibited by the C3d ligand in the INS-1E rat beta cell line

L. G. Petersen, J. Størling, P. Heding, S. Li, V. Berezin, J. Saldeen, N. Billestrup, E. Bock, T. Mandrup-Poulsen

Journal:

Year:

2006

Language:

english

File:

PDF, 290 KB

english, 2006

28

The HLA-IDDM association: Implications for etiology and pathogenesis of IDDM

Jern Nerup, Thomas Mandrup-Poulsen, Jens Melvig

Journal:

Diabetes/Metabolism Research and Reviews

Year:

1987

Language:

english

File:

PDF, 1.81 MB

english, 1987

29

ГЛОБАЛЬНАЯ ЭПИДЕМИЯ САХАРНОГО ДИАБЕТА КАК СЛЕДСТВИЕ ПОДОСТРОГО ВОСПАЛЕНИЯ, ОБУСЛОВЛЕННОГО ОБРАЗОМ ЖИЗНИ

KOLB H.,MANDRUP-POULSEN T.

Journal:

Ожирение и метаболизм (Obesity and metabolism)

Year:

2010

Language:

russian

File:

PDF, 745 KB

russian, 2010

30

Indomethacin Treatment Prevents High Fat Diet-induced Obesity and Insulin Resistance but Not Glucose Intolerance in C57BL/6J Mice

Fjære, Even, Aune, Ulrike L., Røen, Kristin, Keenan, Alison H., Ma, Tao, Borkowski, Kamil, Kristensen, David M., Novotny, Guy W., Mandrup-Poulsen, Thomas, Hudson, Brian D., Milligan, Graeme, Xi, Yanna

Journal:

Journal of Biological Chemistry

Year:

2014

Language:

english

File:

PDF, 986 KB

english, 2014

31

Ciliary neurotrophic factor potentiates the beta-cell inhibitory effect of IL-1beta in rat pancreatic islets associated with increased nitric oxide synthesis and increased expression of inducible nitric oxide synthase

Wadt, K. A., Larsen, C. M., Andersen, H. U., Nielsen, K., Karlsen, A. E., Mandrup-Poulsen, T.

Journal:

Year:

1998

Language:

english

File:

PDF, 280 KB

english, 1998

32

Genetically determined differences in newborn rat islet sensitivity to interleukin-1 in vitro: no association with the diabetes prone phenotype in the BB-rat

Andersen, H. U., Mandrup-Poulsen, T., Egeberg, J., Helqvist, S., Nerup, J.

Journal:

European Journal of Endocrinology

Year:

1989

Language:

english

File:

PDF, 724 KB

english, 1989

33

The anti-interleukin-1 in type 1 diabetes action trial—background and rationale

Linda M.S. Pickersgill, Thomas R. Mandrup-Poulsen

Journal:

Diabetes/Metabolism Research and Reviews

Year:

2009

Language:

english

File:

PDF, 73 KB

english, 2009

34

Interleukin-1β induced changes in the protein expression of rat islets: A computerized database

Henrik U. Andersen, Stephen J. Fey, Peter Mose Larsen, Arkadiusz Nawrocki, Kim R. Hejnæs, Thomas Mandrup-Poulsen, Prof. Jørn Nerup

Journal:

ELECTROPHORESIS

Year:

1997

Language:

english

File:

PDF, 1.24 MB

english, 1997

35

Interleukin 1 dose-dependently affects the biosynthesis of (pro)insulin in isolated rat islets of Langerhans

G. A. Spinas, B. S. Hansen, S. Linde, W. Kastern, J. Mølvig, T. Mandrup-Poulsen, C. A. Dinarello, J. H. Nielsen, J. Nerup

Journal:

Year:

1987

Language:

english

File:

PDF, 907 KB

english, 1987

36

19F-heptuloses as tools for the non-invasive imaging of GLUT2-expressing cells

Willy J. Malaisse, Ying Zhang, Karim Louchami, Sonu Sharma, Tom Dresselaers, Uwe Himmelreich, Guy Wayne Novotny, Thomas Mandrup-Poulsen, Daniel Waschke, Yevgeniy Leshch, Julian Thimm, Joachim Thiem, A

Journal:

Archives of Biochemistry and Biophysics

Year:

2012

Language:

english

File:

PDF, 624 KB

english, 2012

37

Age-dependent decline of β-cell function in type 1 diabetes after diagnosis: a multi-centre longitudinal study

Barker, A., Lauria, A., Schloot, N., Hosszufalusi, N., Ludvigsson, J., Mathieu, C., Mauricio, D., Nordwall, M., Van der Schueren, B., Mandrup-Poulsen, T., Scherbaum, W. A., Weets, I., Gorus, F. K., Wa

Journal:

Diabetes, Obesity and Metabolism

Year:

2014

Language:

english

File:

PDF, 501 KB

english, 2014

38

Two-Dimensional Gel Electrophoresis of Rat Islet Proteins: Interleukin 1 -Induced Changes in Protein Expression are Reduced by L-Arginine Depletion and Nicotinamide

Andersen, H. U., Larsen, P. M., Fey, S. J., Karlsen, A. E., Mandrup-Poulsen, T., Nerup, J.

Journal:

Year:

1995

Language:

english

File:

PDF, 5.03 MB

english, 1995

39

Interleukin-6 and Diabetes: The Good, the Bad, or the Indifferent?

Kristiansen, O. P., Mandrup-Poulsen, T.

Journal:

Year:

2005

Language:

english

File:

PDF, 189 KB

english, 2005

40

Skeletal Muscle to Pancreatic β-Cell Cross-talk: The Effect of Humoral Mediators Liberated by Muscle Contraction and Acute Exercise on β-Cell Apoptosis

Christensen, Camilla S., Christensen, Dan P., Lundh, Morten, Dahllöf, Mattias S., Haase, Tobias N., Velasquez, Jessica M., Laye, Matthew J., Mandrup-Poulsen, Thomas, Solomon, Thomas P. J.

Journal:

Journal of Clinical Endocrinology & Metabolism

Year:

2015

Language:

english

File:

PDF, 1.02 MB

english, 2015

41

Numerical Simulation of Salinity and Dissolved Oxygen at Perdido Bay and Adjacent Coastal Ocean

Meng Xia, Paul M. Craig, Christopher M. Wallen, Andrew Stoddard, Jan Mandrup-Poulsen, Machuan Peng, Blake Schaeffer and Zhijun Liu

Journal:

Journal of Coastal Research

Year:

2011

Language:

english

File:

PDF, 3.41 MB

english, 2011

42

The intercellular adhesion molecule-1 K469E polymorphism in type 1 diabetes

Ole. P. Kristiansen, Runa L. Nolsøe, Heidi Holst, Sine Reker, Zenia M. Larsen, Jesper Johannesen, Jørn Nerup, Flemming Pociot, Thomas Mandrup-Poulsen

Journal:

Year:

2000

Language:

english

File:

PDF, 62 KB

english, 2000

43

Complete mutation scan of the human Fas ligand gene: Linkage studies in Type I diabetes mellitus families

R. L. Nolsøe, O. P. Kristiansen, Z. M. Larsen, J. Johannesen, F. Pociot, T. Mandrup-Poulsen

Journal:

Year:

2002

Language:

english

File:

PDF, 71 KB

english, 2002

44

Association of immune mediators at diagnosis of Type 1 diabetes with later clinical remission

N. C. Schloot, P. Hanifi-Moghaddam, N. Aabenhus-Andersen, B. Z. Alizadeh, M. T. Saha, M. Knip, D. Devendra, T. Wilkin, E. Bonifacio, B. O. Roep, H. Kolb, T. Mandrup-Poulsen

Journal:

Diabetic Medicine

Year:

2007

Language:

english

File:

PDF, 357 KB

english, 2007

45

Functional promoter haplotypes of the human FAS gene are associated with the phenotype of SLE characterized by thrombocytopenia

Nolsøe, R L, Kelly, J A, Pociot, F, Moser, K L, Kristiansen, O P, Mandrup-Poulsen, T, Harley, J B

Journal:

Genes and Immunity

Year:

2005

Language:

english

File:

PDF, 163 KB

english, 2005

46

Prevalence of hereditary haemochromatosis in late-onset type 1 diabetes mellitus: a retrospective study

Christina Ellervik, Thomas Mandrup-Poulsen, Børge G Nordestgaard, Lisbeth Enggaard Larsen, Merete Appleyard, Merete Frandsen, Pia Petersen, Poul Schlichting, Torben Saermark, Anne Tybjaerg-Hansen, Hen

Journal:

Year:

2001

Language:

english

File:

PDF, 327 KB

english, 2001

47

Interleukin-1 Antagonism: A Sturdy Companion for Immune Tolerance Induction in Type 1 Diabetes?

Mandrup-Poulsen, T.

Journal:

Year:

2014

Language:

english

File:

PDF, 690 KB

english, 2014

48

Syngeneic Islet Transplantation in Prediabetic BB-DP Rats - A Synchronized Model for Studying, βCell Destruction during the Development of IDDM

Christensen, Ulla Bjerre, Sparre, Thomas, Cooke, Anne, Andersen, Henrik Ullits, Mandrup-Poulsen, Thomas, Nerup, Jørn

Journal:

Year:

1998

Language:

english

File:

PDF, 1.14 MB

english, 1998

49

Response to Comment on: Ellervik et al. Elevated Transferrin Saturation and Risk of Diabetes: Three Population-Based Studies. Diabetes Care 2011;34:2256-2258

Ellervik, C., Mandrup-Poulsen, T., Birgens, H., Nordestgaard, B. G.

Journal:

Year:

2012

Language:

english

File:

PDF, 45 KB

english, 2012

50

A Systematic Comparison of Purification and Normalization Protocols for Quantitative MicroRNA Expressional Profiling in Insulin-Producing Cells

Vestergaard, Anna, Blankestijn, Maaike, Stahl, Jonathan, Pallesen, Emil, Bang-Berthelsen, Claus, Pociot, Flemming, Novotny, Guy, Lundh, Morten, Mandrup-Poulsen, Thomas

Journal:

International Journal of Molecular Sciences

Year:

2016

Language:

english

File:

PDF, 1.74 MB

english, 2016

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